RhodioLife® Rhodiola Rosea | Clinical-Grade Extract in HYBRYD
RhodioLife® Rhodiola Rosea: Why HYBRYD Uses the World’s Most Studied Rhodiola Extract
HYBRYD contains 300mg of RhodioLife® — the first commercially standardized Rhodiola rosea extract, produced by Nektium Pharma in Spain from wild-harvested Siberian root. Most supplement brands use generic, unstandardized Rhodiola. We don’t.
What Is RhodioLife®?
RhodioLife is a branded, standardized extract of Rhodiola rosea root, manufactured by Nektium Pharma SL in Spain. It was the first commercially available standardized Rhodiola extract on the market, and it remains the most clinically studied Rhodiola ingredient in the world, with over 25 years of research behind it.
The raw Rhodiola root is wild-harvested from the Altai Mountains in Siberia under a special export permit issued by the Russian government. Nektium is one of the only companies authorized to source from this region, which produces the highest concentration of bioactive compounds due to extreme altitude, cold, and UV exposure.
Each batch of RhodioLife is standardized to contain a minimum of 3% total rosavins and 1% salidroside — the exact ratio used in the clinical studies on stress adaptation, mental fatigue, and exercise performance. This isn’t a marketing number. It’s verified through UPLC phytochemical fingerprinting and DNA barcoding to confirm genuine Rhodiola rosea root identity.
Why does identity verification matter? The Rhodiola genus contains over 90 species. Many generic Rhodiola supplements use Rhodiola crenulata or other species that have different active compound profiles and are not supported by the same clinical evidence. RhodioLife is verified as authentic Rhodiola rosea using three independent methods: macroscopic identification, DNA barcoding, and UPLC chemical fingerprinting.
RhodioLife® vs. Generic Rhodiola: What You’re Actually Getting
Most Rhodiola supplements on the market don’t disclose their extract source, don’t standardize to clinically validated ratios, and don’t verify species identity. The difference matters because the bioactive profile — and therefore the efficacy — varies dramatically between extracts.
| RhodioLife® (in HYBRYD) | Generic Rhodiola | |
|---|---|---|
| Species Verified | ✓ DNA barcoded | Often unverified |
| Standardization | 3% rosavins, 1% salidroside | Varies or undisclosed |
| Source Region | Altai Mountains, Siberia | Often undisclosed |
| Clinical Studies | Multiple human trials | Typically none on the specific extract |
| Manufacturing | GMP (SGS), FSSC 22000 | Varies |
| Identity Testing | Macroscopic + DNA + UPLC | Rarely triple-verified |
| Third-Party COA | Published | Rarely published |
What the Research Shows
RhodioLife has been studied in both animal models and human clinical trials. The key findings relevant to high-performing professionals and athletes:
Stress Adaptation & Mental Fatigue
A pilot study on participants diagnosed with generalized anxiety disorder found that 340mg/day of RhodioLife for 10 weeks significantly reduced anxiety scores on the Hamilton Anxiety Rating Scale (HAM-A) and depression scores on the Hamilton Depression Rating Scale (HAM-D), with p=0.001 significance.
Exercise Performance & Recovery
In a study comparing Rhodiola rosea (RhodioLife) against Rhodiola crenulata, subjects receiving RhodioLife sustained physical output 25% longer than both the control group and the R. crenulata group. The RhodioLife group also showed less decline in muscle ATP content, suggesting improved mitochondrial energy metabolism during exercise.
Post-Exercise Inflammation
In a human trial with 36 untrained volunteers, those supplemented with RhodioLife (340mg twice daily) for 30 days prior to exhausting exercise showed a significantly blunted rise in C-reactive protein (CRP), a key inflammatory marker. CRP levels returned to baseline only in the RhodioLife group.
Antiviral Protection After Physical Stress
A study on marathon runners found that RhodioLife supplementation exerted antiviral activity following the intense physical stress of a competitive race, suggesting immune-protective benefits during periods of high training load.
The 3:1 rosavin-to-salidroside ratio matters. Multiple studies demonstrate that rosavins — not just salidroside — are critical to the adaptogenic effect. Extracts standardized only to salidroside (common in generic products) miss the synergistic activity of the full rosavin complex. The 3% rosavins / 1% salidroside profile in RhodioLife reflects the natural ratio found in wild Siberian Rhodiola rosea root.
Our Third-Party Test Results
Every batch of RhodioLife used in HYBRYD comes with a Certificate of Analysis from Nektium Pharma. Our current lot (Batch RRE03S6024-0703) was tested January 20, 2025:
Full test results including microbial analysis, heavy metals, pesticides, and residual solvents are available on our Testing & Transparency page.
View Rhodiola COA (PDF)Why RhodioLife® Is in HYBRYD
HYBRYD is a daily performance fuel designed for people who train hard and work harder. Every ingredient is selected for a specific function at a clinically validated dose. RhodioLife fills the stress adaptation role in the formula.
Most people who train regularly and hold demanding jobs are running a chronic cortisol surplus. Caffeine helps them push through it. Rhodiola helps them adapt to it. That’s the difference between borrowing energy and building capacity — and it’s why we pair 300mg of RhodioLife with 100mg of natural caffeine and 200mg of L-Theanine. Acute alertness plus long-term resilience.
We chose RhodioLife specifically — not generic Rhodiola — because the clinical evidence applies to this extract. When a study shows Rhodiola reduces post-exercise inflammation or improves anxiety scores, it was tested using RhodioLife. Using an unstandardized extract and claiming the same benefits would be dishonest.
RhodioLife is expensive. It costs significantly more than generic Rhodiola powder. Most consumer supplement brands won’t use it because it cuts into their margins. We use it because the point of HYBRYD is that every ingredient earns its place.
Try HYBRYD — 5 Days, $15
300mg RhodioLife® Rhodiola + Creapure® Creatine + Lion’s Mane + Cordyceps + Natural Caffeine & L-Theanine. Five packets. No subscription required.
START YOUR TRIALFrequently Asked Questions
What is the difference between RhodioLife and regular Rhodiola?
RhodioLife is a branded, standardized extract of Rhodiola rosea produced by Nektium Pharma in Spain. It is verified for species identity using DNA barcoding, standardized to 3% rosavins and 1% salidroside (the clinically studied ratio), and manufactured under pharmaceutical-grade GMP conditions. Generic Rhodiola supplements often use unverified species, unstandardized extracts, and do not publish third-party testing results.
Where can I buy RhodioLife Rhodiola?
RhodioLife is primarily sold as a B2B ingredient to supplement manufacturers. Very few consumer products contain it due to its cost. HYBRYD Daily Performance Fuel contains 300mg of RhodioLife per serving. You can try it through our 5-day trial for $15 with free shipping.
Why is RhodioLife so expensive compared to generic Rhodiola?
Several factors drive the cost: the raw root is wild-harvested from the Altai Mountains in Siberia under a controlled government permit, it is manufactured in a GMP- and FSSC 22000-certified facility in Spain, each batch undergoes triple identity verification (macroscopic, DNA barcoding, UPLC fingerprint), and it is standardized to precise clinical specifications. Generic Rhodiola skips most or all of these steps.
What dose of RhodioLife is clinically effective?
Clinical studies on RhodioLife have used doses ranging from 200mg to 680mg per day. The anxiety study used 340mg/day, the exercise recovery study used 680mg/day (340mg twice daily), and effects on physical performance have been documented at 200-400mg/day. HYBRYD contains 300mg per serving, which falls within the effective range for daily stress adaptation and cognitive support.
Is HYBRYD the only supplement that contains RhodioLife?
Not the only one globally, but RhodioLife is rarely found in consumer products — especially in the U.S. market. Most products that use it are European standalone Rhodiola capsules sold through specialty retailers. HYBRYD is one of the only American consumer products that includes RhodioLife as part of a clinically dosed daily performance formula.
What are rosavins and salidroside?
Rosavins (including rosavin, rosarin, and rosin) and salidroside are the primary bioactive compounds in Rhodiola rosea root. Rosavins are unique to the R. rosea species and are not found in other Rhodiola species like R. crenulata. Salidroside is present across multiple species. Research indicates the adaptogenic and performance benefits come from the combination of both compound groups, which is why the 3:1 rosavin-to-salidroside ratio used in RhodioLife matches what occurs naturally in wild Siberian root.
Do you publish your test results?
Yes. We publish full third-party test results for every ingredient in HYBRYD, including our RhodioLife Rhodiola. You can view potency verification, heavy metals testing, and microbial analysis on our Testing & Transparency page, and download the original Certificate of Analysis directly.
References
Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T. Effect of Extracts from Rhodiola Rosea and Rhodiola Crenulata (Crassulaceae) Roots on ATP Content in Mitochondria of Skeletal Muscles. Bull Expo Biol Med. 2003;136(6):585–7.
Abidov M et al. Effect of RhodioLife on CRP and CK after exhaustive exercise. Bull Exp Biol Med. 2004;7:63–4.
Bystritsky A, et al. A Pilot Study of Rhodiola rosea (Rhodiolife) for Generalized Anxiety Disorder (GAD). J. Altern. Complement. Med. 14, 175–180 (2008).
Ahmed M, et al. Rhodiola rosea (Rhodiolife) Exerts Antiviral Activity in Athletes Following a Competitive Marathon Race. Front. Nutr. 2, 1–7 (2015).
Dimpfel W, Schombert L, Vega-Morales T, Wiebe JC. Neuropharmacological Characterization of Extracts from Rhodiola rosea, Oenothera paradoxa and Paullinia cupana in Comparison to Caffeine. Pharmacol Pharm. 2016;7(7).
Pooja, et al. Anti-inflammatory Activity of Rhodiola rosea – “A Second-generation Adaptogen”. Phytother. Res. 23, 1099–102 (2009).
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. RhodioLife® is a registered trademark of Nektium Pharma SL.